SynbiDrug-R Data Browser


Query Results for Trifluoperazine

Drug Information


PubChem CID Drug (INN) Original Targets (Gene Symbol) Original Indications
5566 trifluoperazine ADCY1, ADCY3, ADCY4, ADCY6, ADCY8, ADCY9, ADRA1A, ANXA10, ANXA13, ANXA2, ANXA3, ANXA5, ANXA6, CALM1, CALY, DRD2, DRD4, DRD5, F2, FDPS, GRK7, LTB4R, MYH1, MYH2, MYH4, MYH7B, MYL1, MYL12A, MYL2, MYL7, MYL9, MYLK, MYO15A, MYO18B, MYO1C, MYO1D, MYO1E, MYO3A, MYO3B, MYO5B, MYO5C, NDUFAF3, NDUFS5, S100A4, SLC1A5, SLC5A11, SLC7A5, TNNC1, TNNI3, TNNT2 Antipsychotic Agents, Antiemetics, Alcoholic Intoxication, Chronic, Bipolar Disorder, Catatonia, Hallucinations, Psychotic Disorders, Schizophrenia, Paranoid Schizophrenia, Brain Injuries, Mental deficiency, Alcoholism, Alcohol abuse, Bipolar disorder, Bipolar I disorder, Hallucination, Psychotic disorder, Schizophrenia, paranoid type, Brain injury

Predicted Targets

Drug Name
(INN)		 Predicted Drug Target
(Uniprot AC)		 Target Prediction Score
(Range: 0~1)		 Binding or Not
(Positive binding: 1)		 Novel Positives
(Novel candidate: 1)
trifluoperazine DRD1 (P21728) 0.1042 0 -
trifluoperazine M6PR (P20645) 0.1042 0 -
trifluoperazine CCNB1 (P14635) 0.1041 0 -
trifluoperazine GRIA1 (P42261) 0.1041 0 -
trifluoperazine AVPR1B (P47901) 0.104 0 -
trifluoperazine BCL2 (P10415) 0.104 0 -
trifluoperazine GRM6 (O15303) 0.104 0 -
trifluoperazine PROC (P04070) 0.104 0 -
trifluoperazine P08170 0.1039 0 -
trifluoperazine UPP1 (Q16831) 0.1039 0 -
trifluoperazine TACR3 (P29371) 0.1038 0 -
trifluoperazine CTSF (Q9UBX1) 0.1038 0 -
trifluoperazine TRPA1 (O75762) 0.1038 0 -
trifluoperazine PLA2G7 (Q13093) 0.1038 0 -
trifluoperazine HTR2C (P28335) 0.1036 0 -
trifluoperazine KCNS3 (Q9BQ31) 0.1036 0 -
trifluoperazine P10185 0.1035 0 -
trifluoperazine LIPA (P38571) 0.1035 0 -
trifluoperazine KDM4E (B2RXH2) 0.1033 0 -
trifluoperazine PLD4 (Q96BZ4) 0.1033 0 -
trifluoperazine GLRA2 (P23416) 0.1032 0 -
trifluoperazine KCND2 (Q9NZV8) 0.1032 0 -
trifluoperazine GRIN3A (Q8TCU5) 0.1032 0 -
trifluoperazine GABRE (P78334) 0.1031 0 -
trifluoperazine AMY2A (P04746) 0.1031 0 -
trifluoperazine DHFR (P00374) 0.103 0 -
trifluoperazine SLC5A4 (Q9NY91) 0.103 0 -
trifluoperazine PSMA4 (P25789) 0.1027 0 -
trifluoperazine CYP3A4 (P08684) 0.1027 0 -
trifluoperazine TBXAS1 (P24557) 0.1027 0 -
trifluoperazine IFNL1 (Q8IU54) 0.1027 0 -
trifluoperazine GUCY1B1 (Q02153) 0.1026 0 -
trifluoperazine MCM6 (Q14566) 0.1026 0 -
trifluoperazine ALOX12B (O75342) 0.1026 0 -
trifluoperazine GRIA2 (P42262) 0.1025 0 -
trifluoperazine ND1 (P03886) 0.1024 0 -
trifluoperazine KCNK2 (O95069) 0.1024 0 -
trifluoperazine CACNA1S (Q13698) 0.1024 0 -
trifluoperazine O54735 0.1024 0 -
trifluoperazine LPAR3 (Q9UBY5) 0.1022 0 -
trifluoperazine CYP26A1 (O43174) 0.1021 0 -
trifluoperazine F7 (P08709) 0.1019 0 -
trifluoperazine SERPINA6 (P08185) 0.1019 0 -
trifluoperazine HRH2 (P25021) 0.1018 0 -
trifluoperazine OGA (O60502) 0.1018 0 -
trifluoperazine O78750 0.1018 0 -
trifluoperazine CACNA2D4 (Q7Z3S7) 0.1018 0 -
trifluoperazine P09464 0.1018 0 -
trifluoperazine TUBB2A (Q13885) 0.1016 0 -
trifluoperazine PDE6C (P51160) 0.1016 0 -
Total 48 positive target(s) from 1301 results
Page 9 of 27

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Predicted Mechanisms

Drug
(INN)		 Drug Mechanism
(Gene ontology)		 Mechanism Score
(Range: 0~1)		 Positive or not
(Positive: 1)
trifluoperazine GO:0006281 DNA repair 1 1
trifluoperazine GO:0031570 DNA integrity checkpoint 1 1
trifluoperazine GO:0007049 cell cycle 0.875 1
trifluoperazine GO:0008283 cell population proliferation (viability) 0.7 1
trifluoperazine GO:0071456 cellular response to hypoxia 0.3333 0
trifluoperazine GO:0001525 angiogenesis 0.2857 0
trifluoperazine GO:0008283 cell population proliferation 0.25 0
trifluoperazine GO:0006954 inflammatory response 0.2 0
trifluoperazine GO:0008219 cell death 0.0625 0
trifluoperazine GO:0006096 glycolytic process 0 0
trifluoperazine GO:0016477 cell migration 0 0
trifluoperazine GO:0001837 epithelial to mesenchymal transition 0 0
trifluoperazine GO:0002418 immune response to tumor cell 0 0
trifluoperazine GO:0010833 telomere maintenance via telomere lengthening 0 0
trifluoperazine GO:0001570 vasculogenesis 0 0
trifluoperazine GO:0007155 cell adhesion 0 0
trifluoperazine GO:0016049 cell growth 0 0
trifluoperazine GO:0006915 apoptotic process 0 0
Total 4 positive mechanism(s) from 18 results

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Predicted Cancer Indication Score

Drug
(INN)		 Cancer Type Indication Score
(Range: 0~1)		 Cancer Drug or Not
(Positive indication: 1)		 Novel Positives
(Novel candidate: 1)
trifluoperazine Cancer(general) 0.6236 0 -

Last update: 2022-03-02